2011

主な論文・総説・著書

1. Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure. Keita Un, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida. J Controlled Release. 20. 355-363. 2011
2. The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose- modified lipoplexes. Keita Una, Shigeru Kawakamia, Mitsuru Yoshidaa, Yuriko Higuchia, Ryo Suzuki,Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashidaa. Biomaterials. 32. 4659-69. 2011
3. Local Gene Delivery System by Bubble liposomes and Ultrasound exposure into Joint Synovium. Yoichi Negishi, Yuka Tsunoda, Yoko Endo-Takahashi, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Matsuo Yamamoto, and Yukihiko Aramaki. J. Drug Delivery  203986, 2011
4. Bubble liposomes and ultrasound promoted endosomal escape of TAT-PEG liposomes as gene delivery carriers. Omata D, Negishi Y, Hagiwara S, Yamamura S, Endo-Takahashi Y, Suzuki R, Maruyama K, Nomizu M, Aramaki Y.  Mol. Pharm. 8. 2416-23. 2011
5. Combination of ultrasound and bubble liposome enhance the effect of doxorubicin and inhibit murine osteosarcoma growth. Ueno Y, Sonoda S, Suzuki R, Yokouchi M, Kawasoe Y, Tachibana K, Maruyama K, Sakamoto T, Komiya S.  Cancer Biol Ther., 12, 270-277, 2011
6. Computed tomography imaging of transferrin targeting liposomes encapsulating both boron and iodine contrast agents by convection-enhanced delivery to F98 rat glioma for boron neutron capture therapy. S. Miyata, S. Kawabata, R. Hiramatsu, A. Doi, N. Ikeda, T. Yamashita, T. Kuroiwa, S. Kasaoka, K. Maruyama, S. Miyatake. Neurosurgery. 68. 1380-1387. 2011
7. A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors. Kouichi Shiraishi, Reiko Endoh, Hiroshi Furuhata, Masamichi, Nishihara, Yusuke Oda, Ryo Suzuki, Kazuo Maruyama, Jun-ichiro Jo, Yasuhiko Tabata, Jun Yamamoto, Masayuki Yokoyama, Int. J. Pharm., 421, 379-387, 2011
8. Suppression of melanoma growth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier. Keita Un, Shigeru Kawakami, Ryo Suzuki, Kazuo Maruyama, Fumiyoshi Yamashita and Mitsuru Hashida. Molecular Pharmaceutics. 8, 543-554, 2011
9. Delivery of an Angiogenic Gene into Ischemic Muscle by Novel Bubble Liposomes Followed by Ultrasound Exposure. Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki, Yuuki Matsuki, Norio Takagi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. Pharm. Res., 28. 712-719. 2011
10. Ultrasound-mediated Transfection with Liposomal Bubbles Delivers Plasmid DNA Directly into Nucleus. Takeshi Kawazu, Kazumi Hakamada, Yusuke Oda, Jun Miyake, Kazuo Maruyama and Takeshi Nagasaki. Chemistry Letters. 40 (3). 298-299. 2011
11. Multi-functional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy. Kenji Kono, Seiji Nakashima, Daisuke Kokuryo, Ichio Aoki, Hiroaki Shimomoto, Sadahito Aoshima, Kazuo Maruyama, Eiji Yuba, Chie Kojima, Atsushi Harada and Yukihito Ishizaka. Biomaterials, 32, 1387-1395, 2011
12. Synergistic effect of ultrasound and antibiotics against Chlamydia trachomatis-infected human epithelial cells in vitro. Yurika Ikeda-Dantsuji, Loreto B. Feril Jr., Katsuro Tachibana, Koichi Ogawa, Hitomi Endo, Yoshimi Harada, Ryo Suzuki, Kazuo Maruyama. Ultrasonics Sonochem. 18, 425-430, 2011
13. Enhancement of ultrasonic thrombus imaging using novel liposomal bubbles targeting activated platelet glycoprotein IIb/IIIa complex-in vitro and in vivo study.  Hagisawa K, Nishioka T, Suzuki R, Takizawa T, Maruyama K, Takase B, Ishihara M, Kurita A, Yoshimoto N, Ohsuzu F, Kikuchi M.  Int. J. Cardiol. 152, 202-206, 2011
14. リポソームと遺伝子発現タグを利用したがん細胞に対する新規アクティブターゲティングシステムの開発（The liposome-based targeting system　by the combination of tag ligand and genetically expressed tag protein）佐藤紗也佳, 真柴拓哉, 本田亜紀, Citterio Daniel, 小田雄介, 鈴木　亮, 丸山一雄, 鈴木孝治Progress in Drug Delivery System, 20, 103-108, 2011.
15. 超音波応答性リポソームの開発とその医療応用に向けた基礎的検討　　鈴木亮、小田雄介、丸山一雄　超音波TECHNO、23、81-84、2011
16. Progress in the development of ultrasound-mediated gene delivery systems utilizing nano- and microbubbles, Ryo Suzuki, Yusuke Oda, Naoki Utoguchi, Kazuo Maruyama,J. Controlled Release. 149, 36-41, 2011
17. Intracellular targeting delivery of liposomal drugs for tumor delivery based on EPR effects, Kazuo Maruyama, Advanced Drug Delivery Rev., 63, 161-169, 2011
18. 超音波応答性リポソームの開発とその医療応用に向けた基礎的検討　　鈴木亮、小田雄介、丸山一雄　超音波TECHNO、23、81-84、2011
19. バブルリポソームと超音波を利用した薬物・遺伝子デリバリー.　小田雄介、丸山一雄　医学の歩み (医歯薬出版株式会社) 238 (2) 169-173. 2011
20. トランスフェリン修飾リポソームによる細胞内送達とがん治療への応用、平田圭一・鈴木　亮・小田雄介・野村　鉄也・宇都口直樹・丸山一雄、　日本血液代替物学会会誌「人工血液」　19, 17-24, 2011
21. リポソーム技術と超音波技術を基盤とした革新的がん治療システムの構築、鈴木亮、小田雄介、平田圭一、野村鉄也、宇都口直樹、丸山一雄、ケミカルエンジニアヤリング　（化学工業社）　56(2), 50-54, 2011
22. Ultrasound-targeted bubble liposome destruction enhances AG73-mediated gene transfer by improvement of intracellular trafficking.  Daiki Omata, Yoichi Negishi, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Motoyoshi Nomizu, and Yukihiko Aramaki.  10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 326-329. Melville, New York, 2011
23. Characterisation of gene delivery using liposomal bubbles and ultrasound.  Risa Koshima, Ryo Suzuki, Yusuke Oda Keiichi Hirata, Tetsuya Nomura, Yoichi Negishi, Naoki Utoguchi, Nobuki Kudo and Kazuo Maruyama. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 330-334. Melville, New York, 2011
24. Intramuscular injection of angiogenic gene with bubble liposomes followed by ultrasound exposure to improve angiogenesis.  Yoichi Negishi, Keiko Matsuo, Yoko Endo-Takahashi, Kentaro Suzuki, Yuuki Matsuki, Norio Takagi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 335-399.  Melville, New York, 2011
25. Novel siRNA-loaded bubble liposomes with ultrasound exposure for RNA interference.  Yoko Endo-Takahashi, Yoichi Negishi, Ryo Suzuki, Kazuo Maruyama, and Yukihiko Aramaki. 10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 340-344. Melville, New York, 2011
26. Anti-tumor mechanism in IL-12 gene therapy using liposomal bubbles and ultrasound. Ryo Suzuki, Yusuke Oda, Risa Koshima, Keiichi Hirata Tetsuya Nomura, Yoichi Negishi, Naoki Utoguchi Shinsaku Nakagawa and Kazuo Maruyama.  10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 345-350. Melville, New York, 2011
27. Anti-tumor effects from dendritic cell-based cancer immunotherapy using liposomal bubbles and ultrasound. Yusuke Oda, Ryo Suzuki, Keiichi Hirata, Tetsuya Nomura, Naoki Utoguchi and Kazuo Maruyama.  10TH INTERNATIONAL SYMPOSIUM ON THERAPEUTIC ULTRASOUND (ISTU 2010) (Ed by Yoichiro Matsumoto, Lawrence A. Crum, Gail Reinette ter Haar), pp. 351-355. Melville, New York, 2011
28. 分布（第2章-２）丸山一雄、生物薬剤学ー薬の生体内運命　PP.40-54,　朝倉書店、東京　2011,　2月25日　
29. リポソーム研究はおもしろい　丸山一雄　薬剤学 71. 301. 2011

主な発表（国際会議、国内学会など）

1. Cancer immunotherapy utilized ultrasound sensitive liposomes (Bubble liposomes). Kazuo Maruyama. Liposomes in Jerusalem 2011. May 15th-19th, 2011.Jerusalem, Israel
2. リポソームテクノロジーを基盤とするDDSの構築とその応用. 丸山一雄.　三大学医工薬連環科学シンポジウム.　2011年１月13日　大阪（関西大学）
3. 患者にやさしい薬物治療　ジェネリック医薬品とバリアフリー製剤　丸山一雄　　平成23年度　市民大学講座　（帝京大学薬学部主催）　2011年9月11日　相模原市　ソレイユさがみ