2014

主な論文・総説・著書

Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes, Mitsuru Yoshida, Shigeru Kawakami, Yusuke Kono, Keita Un, Yuriko Higuchi, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida. Int. J. Pharm. In press 2014
Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice. Kurosaki T, Kawakami S, Higuchi Y, Suzuki R, Maruyama K, Sasaki H, Yamashita F, Hashida M. Nanomedicine : nanotechnology, biology, and medicine In press 2014
Anti-tumor effect of NF-ĸB decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites. Kono Yusuke, Kawakami Shigeru, Higuchi Yuriko, Maruyama Kazuo, Yamashita Fumiyoshi, Hashida Mitsuru. Cancer Science. 105, 1049-1055, 2014
Tumour-associated macrophages targeted transfection with NF-κB decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice. Yusuke Kono, Shigeru Kawakami, Yuriko Higuchi, Kazuo Maruyama, Fumiyoshi Yamashita, Mitsuru Hashida. J. Drug Targeting, 22, 439-449, 2014.
Gene Delivery to Periodontal Tissue using Bubble Liposomes and Ultrasound. Marika Sugano, Yoichi Negishi, Yoko Endo-Takahashi, Nobuhito Hamano, Michihiko Usui, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki, Matsuo Yamamoto. J. Periodontal Res. 49, 398-404, 2014
Evaluation of active control of Bubble liposomes in a bifurcated flow under various ultrasound conditions. Ren Koda, Jun Koido, Naoto Hosaka, Shinya Onogi, Takashi Mochizuki, Kohji Masuda, Ryo Suzuki, Kazuo Maruyama. Advanced Biomedical Engineering 3, 21-28, 2014
Bubble liposomes and ultrasound exposure improve localized morpholino oligomer delivery into the skeletal muscles of dystrophic mdx mice. Yoichi Negishi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Shoko Sekine, Takuo Kojima, Sayaka Mayama, Taiki Kikuchi, Nobuhito Hamano, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Yukihiko Aramaki.　 Molecular Pharmaceutics 11, 1053-1061, 2014
Combination of Bubble liposomes and high-intensity focused ultrasound (HIFU) enhanced antitumor effect by tumor ablation. Nobuhito Hamano, Yoichi Negishi, Kyohei Takatori, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Takuro Niidome, Yukihiko Aramaki. Biological & Pharmaceutical Bulletin 37(1), 174-177, 2014.
Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice, Tomoaki Kurosaki, Shigeru Kawakami, Yuriko Higuchi, Ryo Suzuki, Kazuo Maruyama, Hitoshi Sasaki, Fumiyoshi Yamashita, and Mitsuru Hashida, J. Control. Release 176, 24-34, 2014
Systemic delivery of miR-126 by miRNA-loaded Bubble liposomes for the treatment of hindlimb ischemia. Yoko Endo-Takahashi, Yoichi Negishi, Arisa Nakamura, Saori Ukai, Kotomi Ooaku, Yusuke Oda, Katsutoshi Sugimoto, Fuminori Moriyasu, Norio Takagi, Ryo Suzuki, Kazuo Maruyama & Yukihiko Aramaki. Scientific Reports 4, 3883, 2014
小児シロップ剤とマウス空腹時血糖値の変動　　山岡尚世, 齋藤百枝美, 坂本吉正, 渡部多真紀, 丸山一雄, 鈴木亮, 内田佳孝, 望月正人, 丸山桂司, 渡辺茂和, 土屋雅勇, 児玉浩子, 山岡桂子, 平林慎一, Yakugaku-Zasshi 、2014
４種類のリドカイン製剤(院内製剤)における基剤の検討 (The base in four types of lidocain preparation (formulated in Hospital))、山岡尚世, 斎藤百枝美, 丸山桂司, 渡部多真紀, 丸山一雄, 鈴木亮, 渡辺茂和, 土屋雅勇, 内田佳孝, 望月正人, 山辺智代, 山岡桂子, 平林慎一, 　Yakugaku-Zasshi, 134(2), 249-258, 2014
セラノスティクスの構築に向けた超音波応答性バブルリポソームによる遺伝子・核酸デリバリー　根岸洋一、高橋葉子、鈴木亮、丸山一雄、新槇幸彦、Drug Delivery System, 29 (4), 285-293, 2014
.バブルリポソームによる超音波セラノスティクスの開発　丸山一雄　医薬ジャーナル　50 (7) , 95-102, 2014
超音波診断・治療システム（超音波セラノスティックス）開発の現状と展望　鈴木亮, 小田雄介, 小俣大樹, 澤口能一, 根岸洋一, 丸山一雄. INNERVISION　29 (7), 49-52.　2014
バブルリポソームと超音波によるDDS、　鈴木亮、丸山一雄、機能性DDSキャリアの製剤設計Drug Delivery using functional DDS caarriers (監修　岡田弘晃) pp259-268, シーエムシー出版　東京　2014年6月9日
超音波遺伝子導入装置　小俣大樹、丸山一雄　Drug Delivery System, 29 (5), 456-458, 2014.
超音波を利用した新たな診断・治療システムを目指して鈴木亮、丸山一雄　薬事日報　2014