2019

主な論文・総説・著書

1. Scale-up production, characterization and toxicity of a freeze-dried lipid-stabilized microbubble formulation for ultrasound imaging and therapy.  Johan Unga, Saori Kageyama, Ryo Suzuki, Daiki Omata, Kazuo Maruyama.  J. Liposome Res. 30(3), 297-304, 2020 DOI: 10.1080/08982104.2019.1649282
2. The Measurement of Blood Cagulation Process in Extracorporeal circulation Using LED Photoacoustic Imaging, T. Wabe, R. Suzuki, K Maruyama and Y. Uchida, Sensors & Transducers, Vol. 237, pp. 88-94, 2019.
3. Development of antibody-modified nanobubbles using Fc region binding polypeptide for ultrasound imaging. Nobuhito Hamano, Sho Kamoshida, Yamato Kikkawa, Yusuke Yano, Tomomi Kobayashi, Yoko Endo-Takahashi, Ryo Suzuki, Kazuo Maruyama, Yuji Ito, Motoyoshi Nomizu, Yoichi Negishi. Pharmaceuitcs, 11, 283, 2019.  Doi:10.3390/pharmaceutics11060283
4. DC-Based Immunotherapy Using Vascular Endothelial Cells Cultured in Conditioned Medium as a Vaccine Antigen Exerts an Anti-Tumor Effect by Inhibiting Angiogenesis.  Makie Yamakawa, Tetsuya Nomura, Mariko Yamagata, Takamasa Hirai, Naoya Koizumi, Kazuo Maruyama, Naoki Utoguchi.   Biol Pharm Bull Reports  2, 99-105, 2019  DOI: https://doi.org/10.1248/bpbreports.2.6_99
5. Devlopment of dendritic cell-based immunotherapy targeting tumor blood vessels in a mouse model of lung metastasis. Tetsuya Nomura, Makie Yamakawa, Takuto Shimaoka, Takamasa Hirai, Naoya Koizumi, Kazuo Maruyama, Naoki Utoguchi. Biol Pharm Bull, 42(4), 645-648, 2019. doi: 10.1248/bpb.b18-00737.
6. Lipid nanoparticles of Type-A CpG D35 suppress tumor growth by changing tumor immune-micro environment and activate CD8 T cells in mice.  Lisa Munakata, Yoshihiko Tanimoto, Akio Osa, Jie Meng, Yasunari Haseda, Yujiro Naito, Hirotomo Machiyama, Atsushi Kumanogoh, Daiki Omata, Kazuo Maruyama, Yasuo Yoshioka, Yoshiaki Okada, Shohei Koyama, Ryo Suzuki, Taiki Aoshi.  J. Control Release  313，106-119，2019  https://doi.org/10.1016/j.jconrel.2019.09.011
7. Evaluation of the theranostic potential of perfluorohexane-based acoustic nanodroplets.  Rodi Abdalkader, Johan Unga, Fumiyoshi Yamashita, Kazuo Maruyama, and Mitsuru Hashidaa. Biol. Pharm. Bull. 42(12), 2038-2044. 2019  DOI:10.1248/bpb.b19-00525
8. Effects of Encapsulated Gas on Stability of Lipid-based Microbubbles and Ultrasound-triggered Drug Delivery.  Daiki Omata, Tamotsu Maruyama, Johan Unga, Fumiko Hagiwara, Lisa Munakata, Saori Kageyama, Tadamitsu Shima, Yuno Suzuki, Kazuo Maruyama, Ryo Suzuki.  J. Control. Release 311-312, 65-73, 2019
9. Viability validation of therapeutic cells according to surrounded amount of microbubbles and ultrasound exposure condition.  Masakazu Seki, Takuya Otsuka, Riki Oitate, Kohji Masuda, Johan Unga, Ryo Suzuki, and Kazuo Maruyama. Japanese Journal of Applied Physics  58, SGGE13, 2019
10. Ultrasound-responsive nanobubble-mediated gene transfection in the cerebroventricular region by intracerebroventricular administration in mice. Koki Ogawa, Yuki Fuchigami, Masayori Hagimori, Kazuo Maruyama, Shintaro Fumoto, Shigeru Kawakami. Euro. J. of Pharmaceutics and Biopharmaceutics. 173, 1-8, 2019 (4.491)
11. Development and evaluation of stability and ultrasound response of DSPC-DPSG-based freeze-dried microbubbles. Johan Unga, Daiki Omata, Nobuki Kudo, Soki Ueno, Lisa Munakata, Tadamitsu Shima, Ryo Suzuki and Kazuo Maruyama．J. Liposoe Res. 29. 368-374. 2019 DOI:10.1080/08982104.2018.1556294
12. 超音波とマイクロバブルによる薬物輸送　小俣大樹、鈴木亮、丸山一雄　　Clinical Neuroscience　37（11），1402-1403, 2019
13. リピッドバブルと超音波によるセラノスティクスと遺伝子・デリバリー　高橋葉子、丸山一雄、根岸洋一　Drug Delivery System　34（2）116-123, 2019
14. 分布（第2章-２）丸山一雄、薬の生体内運命　改訂８版（丸山一雄　編集） PP.64-88,　 ネオメディカル、神奈川　2019,　３月１6日
15. 42.       わかりやすい薬物動態計算問題の解き方（丸山一雄　監修）ネオメディカル、神奈川　2019
16. 超音波セラノスティクス　新開発リピッドバブルを用いて診断して治療する　丸山一雄　帝京大学・帝京大学短期大学　研究シーズ集　2019
17. 薬に技あり！ 秘められた製剤技術の紹介　丸山一雄　　薬学部40周年記念連続講座「大学教授が教える！知って得するお薬と健康の話」2019年度　帝京大学総合博物館　館報　68-74, 2019